For The First Time, Hyperbaric Oxygen Therapy Proven to Reverse Biological Aging in Humans
A landmark study has found that hyperbaric oxygen therapy (HBOT) reverses two key biological signs of aging in humans – the first study to ever make this finding. Published in the peer-reviewed journal Aging, the study shows that it is possible to target and reverse the aging process at the basic cellular-biological level. This breakthrough in the biology of aging provides scientists with a new foundation for investigating ways to slow the aging process.
Two common signs of biological aging are a shortening of telomeres on our chromosomes and the accumulation of senescent cells. Telomeres are like the hardened ends of shoelaces. They protect the ends of chromosomes from deterioration. As we age, our telomeres naturally shorten, but a yearly decrease of their length 20 to 40 bases is associated with serious illnesses. Senescent cells prevent cells from growing and their increase contributes to age-associated conditions.
In the groundbreaking study, patients aged 64 and older underwent a series of HBOT treatments. Multiple blood tests conducted during the study showed HBOT reversed the shortening of telomeres and the accumulation of senescent cells. A medical program developed based on this study is available at Aviv Clinics Dubai.
The “Holy Grail” of the Biology of Aging
The new study is part of an ongoing comprehensive aging research program in the Yitzhak Shamir Medical Center, Israel. A different study released in 2020 showed that hyperbaric oxygen therapy also improves cognitive functions of memory and processing speed, among other areas. The studies have been conducted over the course of a decade of research and caused, Dr. Shai Efrati, the co-author of the study, to develop a unique medical program available at Aviv Clinics Dubai.
According to Efrati, who is the director of the Sagol Center for Hyperbaric Medicine and Research at the Yitzhak Shamir Medical Center,
“After dedicating our HBOT research to exploring its impact on the areas of brain functionality and age-related cognitive decline, we have now uncovered for the first time in humans HBOT’s biological effects at the cellular level in healthy aging adults.”
Efrati called telomere shortening “the ‘Holy Grail’ of the biology of aging” and he developed the medical program at Aviv Clinics based upon the results of over a decade of testing, study, and research.
“The significant improvement of telomere length shown during and after these unique HBOT protocols provides the scientific community with a new foundation of understanding that aging can, indeed, be targeted and reversed at the basic cellular-biological level,” said Efrati, who also is associate professor at the Sackler Faculty of Medicine and Sagol School of Neuroscience at Tel Aviv University.
Study Findings: Hyperbaric Oxygen Therapy Reverses the Aging Process
Efrati co-authored the study with Dr. Amir Hadanny, Chief Medical Research Officer of The Sagol Center for Hyperbaric Medicine and Research. The two focused on testing the impact of HBOT on telomere length and senescent cell concentrations in a non-pathological, aging adult population.
Efrati and Hadanny conducted the prospective trial with 35 healthy, independent adults. None of the patients made any changes to their lifestyle, diet or medication during the study. Each received 60 daily HBOT sessions over the course of 90 days.
Whole blood samples were collected before treatment and again at the 30th and 60th session. Their blood was checked again one to two weeks following the last HBOT session to assess peripheral blood mononuclear cells (PMBCs) telomere length and senescence.
The study found that certain HBOT protocols induced regenerative effects.
Some telomeres increased by more than 20% in length, while senescent cells decreased in number by as much as 37%.
“What is remarkable to note in our study is that in just three months of HBOT, we were able to achieve such significant telomere elongation – at rates far beyond any of the current available interventions or lifestyle modifications,” said Dr. Hadanny.
The HBOT protocol from this study is available in Aviv Clinics, JLT, Dubai. The Aviv Medical Program uses hyperbaric oxygen therapy combined with personalized cognitive and physical training, plus nutrition coaching, to achieve optimal results. Each patient also undergoes extensive assessments and evaluations before, during, and after their 60 HBOT sessions to monitor and analyze progress. The analysis includes MRI brain scans and CPET heart and lung tests, blood tests, motor function, genetic sequencing, and a calculation of the patient’s true biological age based on cellular performance tests.