New Study Shows HBOT Can Reverse the Main Activators of Alzheimer’s Disease and Help Prevent Memory Loss
A groundbreaking new study has brought scientists one step closer to preventing and curing age-related cognitive decline, especially related to early stages of Alzheimer’s disease and dementia.
This landmark study, published in Aging on September 9th, is part of an ongoing program researching age-related cognitive decline. Conducted by the Sagol School of Neuroscience in Tel Aviv and Tel Aviv University, the study marks the first time that hyperbaric oxygen therapy (HBOT)—a non-pharmaceutical method—has proven effective in reversing the main activators and early symptoms of Alzheimer’s disease.
HBOT is a form of oxygen therapy that involves administering 100% pure oxygen to a patient in a pressurized environment. HBOT has been used for decades to treat other conditions, such as non-healing ischemic wounds, but for the first time, it also has shown promise as a potential treatment for reverse the main activators and early symptoms of Alzheimer’s disease and dementia and treat brain and cognitive problems.
A treatment based on this unique protocol is now available at Aviv Clinics Dubai.
Aging and reduced blood flow
The brain is an incredibly complex organism home to a vast network of nerve cells (neurons) that depend on oxygen to thrive. As we age, the number of blood vessels in our brain naturally begins to decline. This causes reduced blood flow to the brain, which in turn causes the brain to receive less oxygen. This decreased blood flow is also known as vascular dysfunction, and it’s a known precursor to Alzheimer’s disease, along with amyloid plaques.
What is an amyloid plaque?
Amyloid plaques are hard, insoluble clusters of proteins formed in the spaces between neurons. They’re formed from beta amyloids—microscopic protein fragments produced by certain cells in the body. In the brain, beta amyloids are found in the fluid between neurons, and a healthy brain usually flushes them out without consequence. However, just like plaque can accumulate on your teeth if you don’t clean them regularly, the same thing can happen in your brain.
As the brain ages, it’s more susceptible to forming amyloid plaques in its blood vessel walls. Once an amyloid plaque forms it can damage the neurons in the brain, ultimately resulting in neuronal death. These plaques are thought to contribute to the progression of Alzheimer’s disease and the cognitive decline associated with it.
For years, scientists have wondered whether or not it’s even possible to dissolve or shrink amyloid plaques. The groundbreaking new study proves for the first time that a unique protocol of HBOT can both reverse amyloid plaques and prevent them from forming in the first place.
How HBOT can reverse amyloid plaques
Study researchers initially used HBOT with mice to understand the effect it has on amyloid plaques. In this first part of the study, researchers delivered HBOT to a group of mice whose brains contained amyloid plaques. The mice received two 60 minute HBOT sessions a day, five days a week for four weeks. The researchers discovered that HBOT significantly reduced the amyloid burden in the mice’s brains, decreasing amyloid plaques by over 30% and shrinking plaques by nearly 19%.
HBOT was also shown to prevent the formation of new amyloid plaques, and the mice exhibited improved performance on cognitive tasks when compared to the control group, giving us evidence that HBOT improved their cognitive functions.
The mice-based study gave promising new evidence that HBOT can be used as both a treatment and a preventative measure for Alzheimer’s disease. Researchers then sought to use the same protocol with human subjects.
The human test group consisted of six patients around age 70, all suffering from mild cognitive impairment. After receiving 60 daily HBOT sessions over a three-month period, the patients saw significant improvements to their cognitive functions, including better memory recall, concentration, and response times.
The researchers theorize that this is due to HBOT’s ability to increase blood flow in the brain. When the brain receives more blood, it receives more oxygen. And when the brain receives more oxygen, it can function at its full capacity.
What this means going forward
The study gives us hope that HBOT can be used as a viable drug-free and non-invasive method to prevent and treat Alzheimer’s disease, bringing us one step closer to preventing and even repairing memory loss and mild cognitive impairment.
“By treating vascular dysfunction, we’re mapping out the path toward Alzheimer’s prevention. More research is underway to further demonstrate how HBOT can improve cognitive function and become an influential tool in the imperative fight against the disease,” affirms Dr. Shai Efrati, one of the investigators conducting the study.
Dr. Efrati is also a medical advisor to Aviv Clinics in The Villages, Florida, which is the only location in the United States to offer the specific HBOT protocol used in this remarkable study. The Aviv Medical Program uses comprehensive testing and assessments before, during, and after the treatment protocol to track progress and provide multidisciplinary clinical team support.
For more information about the Aviv Medical Program, HBOT treatment, and how it may help your brain health, please contact us.
To read the study published in Journal Aging – click here.
Telomeres and Reverse Aging: A Deep Dive into the Connection
Aging seems to be an inescapable part of life: spines shrink, skin wrinkles, and attention spans dissipate. But what if aging was escapable—or at least reversible? What if scientists were able to target the root cause of aging in our very own cells and treat it as if it were an illness?
Researchers in Israel have conducted the world’s first study to prove that biological aging can be reversed:
- Scientists were able to reverse the biological aging process in “thirty-five healthy independently living adults, aged 64 and older.” Through the targeted application of a unique hyperbaric oxygen therapy (HBOT) protocol.
- Telomeres are one of the critical biomarkers of age, and they naturally shorten during the aging process. The research study showed HBOT may help with “increasing telomere length…in the aging populations.”
- These findings are truly groundbreaking, given the accessibility of hyperbaric oxygen treatment. However, Aviv Clinics in central Florida is the only center in the United States to offer this unique HBOT treatment protocol.
So how did these researchers manage to accomplish such a seemingly impossible task that existed only in science fiction just 50 years ago? The answer lies in telomeres—a critical component of your DNA.
What Are Telomeres?
A telomere is a protective cap found at the end of each DNA strand in the human body. They are considered one of “two key hallmarks of the aging process.”
The two types of age to keep in mind are:
- Chronological age, or how many birthdays you have had
- Biological age, or the age that reflects your body’s functions
When considering telomeres, here’s how they manifest in age:
- Short telomeres equate to an older biological age.
- Longer telomeres equate to a healthier, younger biological age.
So it is entirely within reason for a healthy 60-year-old (chronological age) to be much younger (biologically speaking) if they have long, healthy telomeres to continue to protect their cells.
Telomeres and Shoelaces
Telomeres work much like the hardened end caps of shoelaces. Those components on your shoelaces protect the delicate strings they are connected to. Without a protective cap, a shoelace can quickly become frayed and unusable.
As long as the cap persists, a shoelace can stay intact for quite some time. Similarly, telomeres prevent damage from occurring to your underlying DNA:
- With intact telomeres, your cells are protected and they can continue functioning like normal.
- Without telomeres, your cells essentially begin to age and die.
Telomeres and DNA
DNA is a commonly understood component of human biology. Few people go through life consciously thinking about how DNA functions.
Let’s change that with some facts:
- Your DNA contains the biological instructions necessary for your body to continue developing.
- Millions upon millions of cellular processes occur within a human body at any given time.
DNA manages those processes, calmly instructing your cells to divide, consume, and produce complex proteins to stay alive. Telomeres play a vital role in this function.
Telomere Length Naturally Decreases with Age
As we age chronologically, our telomeres naturally shorten. This exposes our DNA, leaving our bodies vulnerable to the diseases and effects of aging.
Some of the common diseases of aging—onset by shortened telomeres—include:
- Heart disease
When the telomeres in your cells become too short, they enter an aged, unhealthy state called senescence. In senescence, a cell can no longer divide to continue replenishing the body’s vital tissues, which makes a person more susceptible to the diseases listed above.
Stress May Impact Telomere Length
External factors like stress can also affect telomere length. The American Psychological Association (APA) reports:
- “Chronic stress and cortisol exposure decrease your supply” of telomerase—the enzyme that replenishes telomeres. So when stress affects your life heavily, you become more susceptible to shorter telomeres.
- Stress is now “one of the most consistent predictors of shorter telomere length.” Exposure to life hardships (e.g., childhood neglect or caregiving in late adulthood) has been particularly noted for its impact on telomere length.
How Aging Manifests
Keep in mind, aging can look different for everyone. Some individuals may notice physical or cognitive changes as they age.
Physical changes may include:
- Wrinkled or sagging skin
- Whitening or graying hair
- Immune, metabolic, kidney, or liver issues
Cognitive changes may include:
- Memory trouble
- Mood shifts
- Slower executive function (e.g., thinking and decision-making, multitasking)
What Is Reverse Aging?
Now for some good news: Whatever type of aging you face, reversing it is possible. When referring to “reverse aging,” we mean biological age. Though chronological aging is inevitable, certain treatments can manage some of the biological shifts that occur because of natural aging and external factors.
The Research Behind Telomeres and Hyperbaric Oxygen Therapy (HBOT)
With the importance of telomeres and aging now understood, most people ultimately want to know:
- How to protect their telomeres, and
- How to repair any degradation that has already occurred.
The scientific research team led by Dr. Shai Efrati, founder and director of the renowned Sagol Center for Hyperbaric Medicine and Research in Israel, proved—for the first time—that reversing biological aging is possible.
By using hyperbaric oxygen therapy (HBOT), Dr. Efrati and his team of scientists were able to increase the length of telomeres in people aged 65 or older by more than 20%.
HBOT involves the patient inhaling pure oxygen in a pressurized environment. This study was conducted on 35 different adults aged 65 and higher. Patients had their blood measured before the study, as well as during the 30th and 60th sessions of HBOT.
The findings were truly unbelievable:
- The telomere length of patients who received HBOT “increased significantly by over 20% following HBOT”—in just three months!
- “There was a significant decrease in the number of senescent [cells],” reducing the number of these dangerous, aging cells with little-to-no telomere length by as much as 37%.
These findings were the basis for creating the cutting-edge HBOT protocol only available at Aviv Clinics.
How Can I Protect My Telomeres?
“Telomere length is genetically determined, with heritability estimates ranging from 44% to 80%.” Fortunately, that still leaves you with a wide margin to protect!
Thankfully, there are many different ways you can protect your existing telomeres and thus control damage and the negative impacts of aging. These include:
1. Exercise Regularly
Research has shown that people with high levels of physical activity have significantly longer telomeres than moderately active or sedentary adults. More specifically, adults who regularly exercise demonstrate a biological age difference of nine years when compared to those who don’t.
2. Maintain a Balanced Diet
Like regular exercise, a balanced diet is crucial in protecting telomere length. High levels of body fat create high levels of oxidative stress—stress that directly affects your cellular integrity.
To protect the length of your telomeres, you must reduce the levels of oxidative stress in your body. Maintaining a healthy, balanced diet rich in antioxidants can provide your DNA with the proper protection it needs to maintain healthy, long telomeres.
3. Avoid Smoking & Alcohol Use
You already know that smoking and drinking alcohol aren’t the healthiest decisions—but did you know that people who smoke have shorter telomeres than those who don’t?
Likewise, people who excessively consume alcohol experience faster levels of biological aging than those who don’t. The science is in: If you’re interested in protecting the length of your telomeres, stay away from tobacco and alcohol.
4. Manage Stress
Stress, especially higher cortisol levels, is one of the main reasons for shortened telomeres. Stress takes many forms, but we are mainly concerned with psychological, chronic, and life-related stress.
These kinds of stress raise the levels of oxidative stress placed on the cells of your immune system. Fortunately, there are many wonderful methods for mitigating stress in our daily lives. Whether it is mindfulness, martial arts, or meditation, you will likely be able to find a method that works best for you.
Fight Aging with Aviv Clinics
Aging manifests differently for everyone, but help is available. Aviv Clinic’s age-related decline program is based on research and has helped many clients restore the youthful vitality they seek and deserve.
If you’d like to learn more about how you can boost your cognitive or physical performance while reversing the effects of aging, contact our team.